Sleep quality in efavirenz-treated Chinese HIV patients–comparing between GT and GG genotype of CYP2B6-516 G/T polymorphisms
Seventy-two adult Chinese HIV-positive treatment-naïve patients were recruited in a study to
evaluate prospectively the associations between CYP2B6 516 G/T polymorphisms and
sleep quality following treatment with an efavirenz-based regimen. Overall, the patients gave
an allelic frequency of 0.3 for CYP2B6 516 T, and a genotype frequency of 9.4% for TT.
Compared to GG, GT gave a higher median value of plasma efavirenz level at four weeks
(3.77 mg/L vs 2.59 mg/L, p< 0.001) and 12 months (3.57 mg/L vs 2.97 mg/L, p= 0.026) …
evaluate prospectively the associations between CYP2B6 516 G/T polymorphisms and
sleep quality following treatment with an efavirenz-based regimen. Overall, the patients gave
an allelic frequency of 0.3 for CYP2B6 516 T, and a genotype frequency of 9.4% for TT.
Compared to GG, GT gave a higher median value of plasma efavirenz level at four weeks
(3.77 mg/L vs 2.59 mg/L, p< 0.001) and 12 months (3.57 mg/L vs 2.97 mg/L, p= 0.026) …
Sleep quality in efavirenz-treated Chinese HIV patients-comparing between GT and GG genotype of CYP2B6-516 G/T polymorphisms.
LSS Lee ShuiShan, TKW To KinWang… - 2014 - cabidigitallibrary.org
Seventy-two adult Chinese HIV-positive treatment-naïve patients were recruited in a study to
evaluate prospectively the associations between CYP2B6 516 G/T polymorphisms and
sleep quality following treatment with an efavirenz-based regimen. Overall, the patients gave
an allelic frequency of 0.3 for CYP2B6 516T, and a genotype frequency of 9.4% for TT.
Compared to GG, GT gave a higher median value of plasma efavirenz level at four weeks
(3.77 mg/L vs 2.59 mg/L, p< 0.001) and 12 months (3.57 mg/L vs 2.97 mg/L, p= 0.026) …
evaluate prospectively the associations between CYP2B6 516 G/T polymorphisms and
sleep quality following treatment with an efavirenz-based regimen. Overall, the patients gave
an allelic frequency of 0.3 for CYP2B6 516T, and a genotype frequency of 9.4% for TT.
Compared to GG, GT gave a higher median value of plasma efavirenz level at four weeks
(3.77 mg/L vs 2.59 mg/L, p< 0.001) and 12 months (3.57 mg/L vs 2.97 mg/L, p= 0.026) …
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